Immunomodulating and Anti-Allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)

Title:Immunomodulating and Anti-Allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)

Volume: 20 Issue: 6

Author(s): Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo

Affiliation:

Keywords: Allergy, fermented grape marc, polyphenols, lymphocytes, polymorphonuclear cells, monocytes.

Abstract: Polyphenols contained in FGM from Negroamaro (N) and Koshu (K) Vitis vinifera have been shown to exhibit several immunomodulating activities. For instance, mice affected by experimental colitis when administered with K-FGM showed an attenuation of the inflammatory process. In murine asthma, K-FGM reduced IgE production and eosinophil number in bronchial alveolar lavage fluid. In vitro, both N- and K-FGM were able to induce T regulatory cells in terms of Foxp-3 molecule expression and release of interleukin-10. In another set of experiments both N- and K-FGM were able to balance rate of proliferation/apoptosis/necrosis of normal human peripheral lymphocytes, thus indicating the property of these compounds to maintain immune homeostatic mechanisms in the host. On the other hand, N- and K-FGM inhibited human basophil degranulation, thus, confirming our previous results obtained with rat basophilic leukemia cells. Finally, N- and K-FGM also decreased oxidative burst of human polymorphonuclear cells and monocytes.Taken together, these findings imply the potential clinical usefulness of FGM administration in inflammatory/allergic conditions, such as chronic asthma.

Cite this article as:

Marzulli Giuseppe, Magrone Thea, Vonghia Luisa, Kaneko Masahiro, Takimoto Hiroaki, Kumazawa Yoshio and Jirillo Emilio, Immunomodulating and Anti-Allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM), Current Pharmaceutical Design 2014; 20 (6) . https://dx.doi.org/10.2174/138161282006140220120640