The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

Title:The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration

Volume: 9 Issue: 3

Author(s): Wenjing Yu, Zhen Liu, Shu An, Jinyi Zhao, Lan Xiao, Yongchao Gou, Yunfeng Lin and Jun Wang

Affiliation:

Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).

Abstract: Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone.

Cite this article as:

Yu Wenjing, Liu Zhen, An Shu, Zhao Jinyi, Xiao Lan, Gou Yongchao, Lin Yunfeng and Wang Jun, The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration, Current Stem Cell Research & Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574888X09666140213154144