Facile Synthesis of 1,2,4-trisubstituted Imidazoles via Aerobic Copper Catalyzed Ligand-free [3+2] Cycloaddition

Title:Facile Synthesis of 1,2,4-trisubstituted Imidazoles via Aerobic Copper Catalyzed Ligand-free [3+2] Cycloaddition

Volume: 11 Issue: 5

Author(s): Wei Li, Weixiang Jiao Wan Tian and Ming Lei

Affiliation:

Keywords: Copper catalyzed reaction, nitroolefin, amidine, [3+2] cycloaddition, imidazole derivatives.

Abstract: A simple and facile approach to highly functionalized imidazole derivatives in moderate to good yields has been developed. This method involves copper catalyzed aerobic [3+2] cycloaddition of amidines with nitroolefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.

Cite this article as:

Li Wei, Tian Jiao Wan Weixiang and Lei Ming, Facile Synthesis of 1,2,4-trisubstituted Imidazoles via Aerobic Copper Catalyzed Ligand-free [3+2] Cycloaddition, Letters in Organic Chemistry 2014; 11 (5) . https://dx.doi.org/10.2174/1570178611666140207221202