Abstract
Ambruticin is a unique example of antibiotics isolated from the fermentation media of gliding bacteria. Since the last decade, it has emerged as one of the most intensively studied derivative due to its oral antibiotic properties and due to its unique architecture. This structurally exceptional molecule bearing ten stereogenic centers contains a tetrahydropyranyl ring, a divinylcyclopropyl ring, and a dihydropyranyl ring linked to each other via three (E) double bonds. This review is aimed at highlighting the recent progresses in the area, including the biological activity, a comparison of the 4 total syntheses and the original strategies developed for the partial syntheses.
Keywords: carbohydrate, c-nucleosides, fermentation, chemical transformations, kendes approach, amphotericin b, olefination reaction
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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