Tetraoxanes as Antimalarials: Harnessing the Endoperoxide

Title:Tetraoxanes as Antimalarials: Harnessing the Endoperoxide

Volume: 14 Issue: 2

Author(s): Laura C. Fisher and Margaret A.L. Blackie

Affiliation:

Keywords: Endoperoxide, malaria, plasmodium falciparum, tetraoxane.

Abstract: With the emergence of resistance to artemesinin, the need for new antimalarial compounds is pressing. Several research groups have made significant contributions to the exploration of the use of 1,2,4,5-tetraoxanes and 1,2,4- trioxanes as synthetic analogues of artemesinin. This short review highlights the recent developments in this field detailing both biological results and useful synthetic methodology. In addition, the current understanding of the mode of action of this class of compounds has been described.

Cite this article as:

Fisher C. Laura and Blackie A.L. Margaret, Tetraoxanes as Antimalarials: Harnessing the Endoperoxide, Mini-Reviews in Medicinal Chemistry 2014; 14 (2) . https://dx.doi.org/10.2174/1389557514666140123144942