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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

MicroRNA-34a: Role in Cancer and Cardiovascular Disease

Author(s): Xi Chen, Jian-Ya Zhou and Jian-Ying Zhou

Volume 15, Issue 4, 2014

Page: [361 - 373] Pages: 13

DOI: 10.2174/1389450115666140120102935

Price: $65

Abstract

Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.

Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.

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