Abstract
A modified method for the synthesis of a series of substituted benzenesulfonamides from benzenesulfonylchloride and substituted amines (1:1) in aqueous media have been adopted at controlled pH (8-10). Transition metal complexes of synthesized ligands were also prepared by refluxing ligands and metal salts (2:1) for one hour. The synthesized compounds have been characterized by spectroscopic techniques (FTIR, 1HNMR and mass spectrometry). Synthesized compounds were analyzed for their activity toward acetyl cholinesterase (AChE) inhibition, butyrylcholinesterase (BChE) inhibition, lipoxygenase (LOX) inhibition, antioxidant (DPPH) and antiurease. As regards biological activities of ligands, only N-(2-nitrophenyl) benzenesulfonamide (3) showed appreciated value of IC50= 77.13± 00 mole against LOX while all metal complexes showed low activities. Cu complex (C-4) showed moderate activity against LOX while all the other metal complexes had no activity against any enzyme at all. Similarly Zn complexes (Z-2 to Z-6) showed little activity against AChE but the ligands showed no significant activity against any other. Metal complexes showed high capacity toward antiurease activity.
Keywords: Sulfonamides, metal complexes, biological activity, anti-enzyme activity.
Current Bioactive Compounds
Title:Synthesis of Sulfonamides, Metal Complexes and the Study of In vitro Biological Activities
Volume: 9 Issue: 3
Author(s): Syed Shoaib Ahmad Shah, Muhammad Ashfaq, Tayyaba Najam, Muhammad Mehboob Ahmed, Salma Shaheen, Rukhsana Tabassum and Syeda Abida Ejaz
Affiliation:
Keywords: Sulfonamides, metal complexes, biological activity, anti-enzyme activity.
Abstract: A modified method for the synthesis of a series of substituted benzenesulfonamides from benzenesulfonylchloride and substituted amines (1:1) in aqueous media have been adopted at controlled pH (8-10). Transition metal complexes of synthesized ligands were also prepared by refluxing ligands and metal salts (2:1) for one hour. The synthesized compounds have been characterized by spectroscopic techniques (FTIR, 1HNMR and mass spectrometry). Synthesized compounds were analyzed for their activity toward acetyl cholinesterase (AChE) inhibition, butyrylcholinesterase (BChE) inhibition, lipoxygenase (LOX) inhibition, antioxidant (DPPH) and antiurease. As regards biological activities of ligands, only N-(2-nitrophenyl) benzenesulfonamide (3) showed appreciated value of IC50= 77.13± 00 mole against LOX while all metal complexes showed low activities. Cu complex (C-4) showed moderate activity against LOX while all the other metal complexes had no activity against any enzyme at all. Similarly Zn complexes (Z-2 to Z-6) showed little activity against AChE but the ligands showed no significant activity against any other. Metal complexes showed high capacity toward antiurease activity.
Export Options
About this article
Cite this article as:
Shah Shoaib Ahmad Syed, Ashfaq Muhammad, Najam Tayyaba, Ahmed Mehboob Muhammad, Shaheen Salma, Tabassum Rukhsana and Ejaz Abida Syeda, Synthesis of Sulfonamides, Metal Complexes and the Study of In vitro Biological Activities, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/157340720903140119152646
DOI https://dx.doi.org/10.2174/157340720903140119152646 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
AP5346 (ProLindac™), A DACH Platinum Polymer Conjugate in Phase II Trials Against Ovarian Cancer
Current Bioactive Compounds Emerging Role of Cetuximab in the Treatment of Colorectal Cancer
Recent Patents on Anti-Cancer Drug Discovery TGFβ Signaling in Liver Regeneration
Current Pharmaceutical Design Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles,Pathophysiology and Therapeutic Choices
Current Neuropharmacology Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer
Current Medicinal Chemistry Celiac Disease: Pathogenesis and Novel Therapeutic Strategies
Endocrine, Metabolic & Immune Disorders - Drug Targets Different Treatment Strategies for Pediatric Brain Tumors
Current Pediatric Reviews Hyper-Coagulable Profile with Elevated Pro-Thrombotic Biomarkers and Increased Cerebro- and Cardio-Vascular Disease Risk Exist Among Healthy Dyslipidemic Women
Current Neurovascular Research Radiolabeled Peptides and Proteins in Cancer Therapy
Protein & Peptide Letters Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed/ Refractory Diffuse Large B Cell Lymphoma
Current Stem Cell Research & Therapy Phytosterols: Perspectives in Human Nutrition and Clinical Therapy
Current Medicinal Chemistry Zinc Homeostasis-regulating Proteins: New Drug Targets for Triggering Cell Fate
Current Drug Targets A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects
Current Drug Targets Interaction Between Estrogen Receptor Alpha and Insulin/IGF Signaling in Breast Cancer
Current Cancer Drug Targets TRAIL: A Sword for Killing Tumors
Current Medicinal Chemistry Updates on the Role of FDG-PET/CT in Gynecological Malignancies
Current Molecular Imaging (Discontinued) Inhibition of Early Biochemical Defects in Prodromal Huntington’s disease by Simultaneous Activation of Nrf2 and Elevation of Multiple Micronutrients
Current Aging Science NHE-1: A Promising Target for Novel Anti-cancer Therapeutics
Current Pharmaceutical Design Antiproliferative Effects of Molecular Iodine in Cancers
Current Chemical Biology Recent Advances in the Synthesis of 1,3-Azoles
Current Topics in Medicinal Chemistry