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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

HClO4-SiO2 as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles

Author(s): Siavash Bahari and Akbar Rezaei

Volume 11, Issue 1, 2014

Page: [55 - 58] Pages: 4

DOI: 10.2174/157017861101140113161526

Price: $65

Abstract

An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.

Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO4-SiO2, heterogeneous catalyst.


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