Abstract
An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.
Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO4-SiO2, heterogeneous catalyst.
Letters in Organic Chemistry
Title:HClO4-SiO2 as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles
Volume: 11 Issue: 1
Author(s): Siavash Bahari and Akbar Rezaei
Affiliation:
Keywords: Primary amines, triethyl orthoformate, 1-substituted 1H-1, 2, 3, 4-tetrazole, HClO4-SiO2, heterogeneous catalyst.
Abstract: An efficient and direct protocol is described for the preparation of 1-substituted 1H-1,2,3,4-tetrazoles by the reaction of primary amines, triethyl orthoformate and sodium azide in the presence of catalytic amount of silica-supported perchloric acid under solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.
Export Options
About this article
Cite this article as:
Bahari Siavash and Rezaei Akbar, HClO4-SiO2 as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles, Letters in Organic Chemistry 2014; 11 (1) . https://dx.doi.org/10.2174/157017861101140113161526
DOI https://dx.doi.org/10.2174/157017861101140113161526 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers