Abstract
The studies of new anti-cancer drugs are constantly in the centre of scientific interest. This paper provides an overview of the complex compounds of platinum(II) and palladium(II) as anti-cancer drugs. These drugs have been described in dependence on the type of cells which are under the influence of the cytotoxic drug and side effects arising from the use of the drug. In the case of some drugs such as cisplatin or trans-[PtCl2(tz)2] the mechanisms of action in the body are described. Furthermore, in the paper the methods used for cytotoxicity determination of chemical compounds considered to be used as anticancer drugs are described. The MTT, MTS, LDH, BrdU, Alamar Blue and Neutral Red test are examples of such methods.
Keywords: Cisplatin, cytotoxicity, platinum(II) and palladium(II) complexes.
Current Pharmaceutical Analysis
Title:Platinum(II) and Palladium(II) Complex Compounds as Anti-cancer Drugs. Methods of Cytotoxicity Determination
Volume: 10 Issue: 1
Author(s): Joanna Pranczk, Dagmara Jacewicz, Dariusz Wyrzykowski and Lech Chmurzynski
Affiliation:
Keywords: Cisplatin, cytotoxicity, platinum(II) and palladium(II) complexes.
Abstract: The studies of new anti-cancer drugs are constantly in the centre of scientific interest. This paper provides an overview of the complex compounds of platinum(II) and palladium(II) as anti-cancer drugs. These drugs have been described in dependence on the type of cells which are under the influence of the cytotoxic drug and side effects arising from the use of the drug. In the case of some drugs such as cisplatin or trans-[PtCl2(tz)2] the mechanisms of action in the body are described. Furthermore, in the paper the methods used for cytotoxicity determination of chemical compounds considered to be used as anticancer drugs are described. The MTT, MTS, LDH, BrdU, Alamar Blue and Neutral Red test are examples of such methods.
Export Options
About this article
Cite this article as:
Pranczk Joanna, Jacewicz Dagmara, Wyrzykowski Dariusz and Chmurzynski Lech, Platinum(II) and Palladium(II) Complex Compounds as Anti-cancer Drugs. Methods of Cytotoxicity Determination, Current Pharmaceutical Analysis 2014; 10 (1) . https://dx.doi.org/10.2174/157341291001140102103324
DOI https://dx.doi.org/10.2174/157341291001140102103324 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oleamide Derivatives are Prototypical Anti-Metastasis Drugs that Act by Inhibiting Connexin 26
Current Drug Safety The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown
Current Medicinal Chemistry Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases
Current Drug Targets Anti-Vascular Endothelial Growth Factor Drug Treatment of Diabetic Macular Edema: The Evolution Continues
Current Diabetes Reviews Design, Synthesis and Anticancer Evaluation of Carbazole Fused Aminopyrimidine Derivatives
Letters in Organic Chemistry Dihydrofolate Reductase as a Target for Chemotherapy in Parasites
Current Pharmaceutical Design Implication of Possible Therapies Targeted for the Tachykinergic System with the Biology of Neurokinin Receptors and Emerging Related Proteins
Recent Patents on CNS Drug Discovery (Discontinued) Hormone Replacement Therapy in Rheumatoid Arthritis
Current Rheumatology Reviews Cell Cycle Regulatory Kinase Modulators: Interim Progress and Issues
Current Topics in Medicinal Chemistry Treatment of Chronic Hypercalcemia
Medicinal Chemistry Targeting DNA Repair Proteins: A Promising Avenue for Cancer Gene Therapy
Current Gene Therapy A Nanostructured Silica-Lipid Hybrid to Facilitate Oral SN-38-based Chemotherapy
Drug Delivery Letters Applications of High Content Screening in Life Science Research
Combinatorial Chemistry & High Throughput Screening Histone Deacetylase Inhibitors: A New Wave of Molecular Targeted Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Sphingolipid Metabolism Enzymes as Targets for Anti-Cancer Therapy
Current Drug Targets Nitroimidazole Radiopharmaceuticals in Hypoxia: Part II Cytotoxicity and Radiosensitization Applications
Current Radiopharmaceuticals Recent Advances of Metal Binding Protein Lactoferrin as an Anti- Microbial Agent
Current Bioactive Compounds Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization
Anti-Cancer Agents in Medicinal Chemistry Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets Current Drug Targets and Future Therapy of Pulmonary Arterial Hypertension
Current Medicinal Chemistry