Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones

Radhe S.      Bahare; Swastika      Ganguly

doi:10.2174/221135251201140102003059

Abstract

A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3^rd and the 5^th position. Some of the compounds have shown promising antimicrobial activity.

Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.

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Anti-Infective Agents

Title:Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones

Volume: 12 Issue: 1

Author(s): Radhe S. Bahare and Swastika Ganguly

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Keywords: Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.

Abstract: A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3^rd and the 5^th position. Some of the compounds have shown promising antimicrobial activity.

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Bahare Radhe S. and Ganguly Swastika, Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones, Anti-Infective Agents 2014; 12 (1) . https://dx.doi.org/10.2174/221135251201140102003059

DOI https://dx.doi.org/10.2174/221135251201140102003059	Print ISSN 2211-3525
Publisher Name Bentham Science Publisher	Online ISSN 2211-3533