An Efficient One-pot Synthesis of Substituted 1, 5-benzoxazepines and 1,5- benzothiazepines Using Potassium Dodecatungstocobaltate Trihydrate (PDTC, K₅CoW₁₂O₄₀.3H₂O) as Heterogeneous Catalyst

Title:An Efficient One-pot Synthesis of Substituted 1, 5-benzoxazepines and 1,5- benzothiazepines Using Potassium Dodecatungstocobaltate Trihydrate (PDTC, K₅CoW₁₂O₄₀.3H₂O) as Heterogeneous Catalyst

Volume: 11 Issue: 2

Author(s): Koilkonda Purandhar, Murugulla Adharvana Chari, Padi Pratap Reddy, Kagga Mukkanti and G. Mahesh Reddy

Affiliation:

Keywords: Potassium Dodecatungstocobaltate Trihydrate, 1, 5-benzoxazepines and 1, 5-benzothiazepines, solvent-free conditions, classical heating or microwave irradiation.

Abstract: An efficient method has been developed for the synthesis of substituted 1,5-benzoxazepines and benzothiazepines under classical heating conditions or microwave irradiation in the presence of an efficient and reusable Potassium Dodecatungstocobaltate Trihydrate (PDTC, K₅CoW₁₂O₄₀.3H₂O) as heterogeneous catalyst which was found to be highly active and afforded excellent yields. The products 6,8,9 and 10 were synthesized using the starting compounds 4a-d, 1 mol% PDTC and achieved in good yields by reflux (70-80%) as well as microwave conditions (60-70%). The reactions of 17a-e with 7, in the presence of 1 mol % PDTC were refluxed in dry ethanol for 6-8 h to isolate the compounds 18a-e in good yields (70-85%) as syrups.

Cite this article as:

Purandhar Koilkonda, Chari Adharvana Murugulla, Reddy Pratap Padi, Mukkanti Kagga and Reddy Mahesh G., An Efficient One-pot Synthesis of Substituted 1, 5-benzoxazepines and 1,5- benzothiazepines Using Potassium Dodecatungstocobaltate Trihydrate (PDTC, K₅CoW₁₂O₄₀.3H₂O) as Heterogeneous Catalyst, Letters in Organic Chemistry 2014; 11 (2) . https://dx.doi.org/10.2174/1570178610999131231123427