Abstract
In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A3-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.
Keywords: Amine, propargylamine, three-component reactions, ZnO.
Combinatorial Chemistry & High Throughput Screening
Title:One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions
Volume: 17 Issue: 5
Author(s): Mona Hosseini-Sarvari and Fatemeh Moeini
Affiliation:
Keywords: Amine, propargylamine, three-component reactions, ZnO.
Abstract: In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A3-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.
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Cite this article as:
Hosseini-Sarvari Mona and Moeini Fatemeh, One-Pot Multi-Component Route to Propargylamines Using Zinc Oxide Under Solvent-Free Conditions, Combinatorial Chemistry & High Throughput Screening 2014; 17 (5) . https://dx.doi.org/10.2174/1386207316666131217104925
DOI https://dx.doi.org/10.2174/1386207316666131217104925 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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