Abstract
Nanosilica chloride was prepared with modification of the surface by applying ultrasonic irradiation and has been employed as an efficient, heterogeneous and effective catalyst in the preparation of 3,4- dihydropyrimidinones (DHPMs) under solvent-free conditions. Simple workup procedure, short reaction time, and good to excellent yield of the product, are other advantages of this catalyst.
Keywords: Nanosilica chloride, multicomponent reactions, ultrasonic irradiation, Biginelli reaction, dihydropyrimidinones, heterogeneous catalyst.