Abstract
The aim of this article is to introduce readers and clarify important issues related to the analysis of trace elements in clinical samples (biological fluids, tissues) using ion chromatography (IC). IC is a convenient analytical method for the analysis of ions in samples also with a complex matrix. However, despite the advances in technology and methodology, it is rather overlooked in the routine analysis of clinical samples. The problems faced by the analyst before and during the analysis of clinical samples and their influence on the interpretation of analytical data are discussed in the following review. Examples of speciation analyses involving IC are also presented. Topics are limited to selected trace elements and all applications described here are taken from published literature.
Keywords: Biofluids, blood, certified reference materials, clinical samples, collection, digestion, dilution, ion chromatography, preservation, serum, storage, toxicity, trace elements, urine, validation.
Current Chromatography
Title:Selected Problems on Ion Chromatography Determinations of Trace Elements in Clinical Samples
Volume: 1
Author(s): Anna Blazewicz
Affiliation:
Keywords: Biofluids, blood, certified reference materials, clinical samples, collection, digestion, dilution, ion chromatography, preservation, serum, storage, toxicity, trace elements, urine, validation.
Abstract: The aim of this article is to introduce readers and clarify important issues related to the analysis of trace elements in clinical samples (biological fluids, tissues) using ion chromatography (IC). IC is a convenient analytical method for the analysis of ions in samples also with a complex matrix. However, despite the advances in technology and methodology, it is rather overlooked in the routine analysis of clinical samples. The problems faced by the analyst before and during the analysis of clinical samples and their influence on the interpretation of analytical data are discussed in the following review. Examples of speciation analyses involving IC are also presented. Topics are limited to selected trace elements and all applications described here are taken from published literature.
Export Options
About this article
Cite this article as:
Blazewicz Anna, Selected Problems on Ion Chromatography Determinations of Trace Elements in Clinical Samples, Current Chromatography 2014; 1 (1) . https://dx.doi.org/10.2174/2213240601999131122114330
DOI https://dx.doi.org/10.2174/2213240601999131122114330 |
Print ISSN 2213-2406 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-2414 |
Related Articles
-
Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-γ Ligand in Chronic Cerebral Hypoperfusion
Current Neurovascular Research Computerized Methods in the Assessment and Prediction of Dementia
Current Alzheimer Research Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions
Current Drug Metabolism Editorial (Thematic Issue: Myokines and Exercise Training: More Shadows than Lights)
Current Pharmaceutical Design Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Review and Meta-Analysis
Current Alzheimer Research Epigenetics in the Cerebrovascular System: Changing the Code without Altering the Sequence
Current Neurovascular Research Depressed or Demented: Common CNS Drug Targets? !
Current Drug Targets - CNS & Neurological Disorders Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD
Current Alzheimer Research Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases
Cardiovascular & Hematological Disorders-Drug Targets Recent Developments on the Studies of Human Memapsin 2 (β-Secretase)
Current Alzheimer Research State-of-the-Art Lentiviral Vectors for Research Use: Risk Assessment and Biosafety Recommendations
Current Gene Therapy “Micromanaging” Glioblastoma Multiforme: The Potential of MicroRNAs, Circular RNAs, and the Hippo Pathway as Novel Treatment Strategies
Current Neurovascular Research Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis
Current Pharmaceutical Design Defining and Regulating Acute Inflammatory Lesion Formation during the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
CNS & Neurological Disorders - Drug Targets Metabolic Alterations in the Outer Membrane Vesicles of Patients with Alzheimer’s Disease: An LC-MS/MS-based Metabolomics Analysis
Current Alzheimer Research A Possible New Diagnostic Biomarker in Early Diagnosis of Alzheimers Disease
Current Alzheimer Research Platelet Function in Inflammatory Diseases: Insights from Clinical Studies
Inflammation & Allergy - Drug Targets (Discontinued) Reduction of β-Amyloid Accumulation by Reticulon 3 in Transgenic Mice
Current Alzheimer Research LW-AFC, A New Formula Derived from Liuwei Dihuang Decoction, Ameliorates Cognitive Deterioration and Modulates Neuroendocrine-Immune System in SAMP8 Mouse
Current Alzheimer Research Pharmacotherapy of Sickle Cell Disease in Children
Current Pharmaceutical Design