Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study

Title:Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study

Volume: 11 Issue: 5

Author(s): Dhruvin R. Shah, Rahul P. Modh, Dhara V. Desai and Kishor H. Chikhalia

Affiliation:

Keywords: Antimicrobial, Antimycobacterial, Minimum Inhibitory Concentration, Quinazolinone; Synthesis, Thiourea, Urea.

Abstract: In an attempt to control multidrug resistant dilemma, a library of quinazolinone based on two novel series was rationalized and synthesized with simple and efficient etiquette. A number of compounds encompass ethyl thioureidic backbone, structurally related to PETT (Phenyl Ethyl Thiazolyl Thiourea) congeners. All the final synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, mass and elemental analysis. The newly synthesized compounds were studied for efficacy against several bacteria (Staphylococcus Aureus, Bacillus Cereus, Escherichia Coli, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Salmonella Typhi, Proteus Vulgaris, Shigella Flexneria) and fungi (Candida Albicans, Aspergillus Niger, Aspergillus Clavatus) using the broth dilution technique. Moreover, these compounds were also screened for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC MGIT method.

Cite this article as:

Shah R. Dhruvin, Modh P. Rahul, Desai V. Dhara and Chikhalia H. Kishor, Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study, Letters in Drug Design & Discovery 2014; 11 (5) . https://dx.doi.org/10.2174/1570180810666131122003517