Poly(ADP-ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors

Title:Poly(ADP-ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors

Volume: 14 Issue: 5

Author(s): Francesca Donà, Ilaria Chiodi, Cristina Belgiovine, Tatiana Raineri, Roberta Ricotti, Chiara Mondello and Anna Ivana Scovassi

Affiliation:

Keywords: Neoplastic transformation, PARP inhibitors, Poly(ADP-ribosylation), Telomeres, 3-aminobenzamide.

Abstract: Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribosylation) play essential roles in several biological processes, among which neoplastic transformation and telomere maintenance. In this paper, we review the poly(ADPribosylation) process together with the highly appealing use of PARP inhibitors for the treatment of cancer. In addition, we report our results concerning poly(ADP-ribosylation) in a cellular model system for neoplastic transformation developed in our laboratory. Here we show that PARP-1 and PARP-2 expression increases during neoplastic transformation, together with the basal levels of poly(ADP-ribosylation). Furthermore, we demonstrate a greater effect of the PARP inhibitor 3-aminobenzamide (3AB) on cellular viability in neoplastically transformed cells compared to normal fibroblasts and we show that prolonged 3AB administration to tumorigenic cells causes a decrease in telomere length. Taken together, our data support an active involvement of poly(ADP-ribosylation) in neoplastic transformation and telomere length maintenance and confirm the relevant role of poly(ADP-ribosylation) inhibition for the treatment of cancer.

Cite this article as:

Donà Francesca, Chiodi Ilaria, Belgiovine Cristina, Raineri Tatiana, Ricotti Roberta, Mondello Chiara and Scovassi Ivana Anna, Poly(ADP-ribosylation) and Neoplastic Transformation: Effect of PARP Inhibitors, Current Pharmaceutical Biotechnology 2013; 14 (5) . https://dx.doi.org/10.2174/138920101405131111104642