Abstract
This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.
Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.
Letters in Organic Chemistry
Title:Synthesis, Spectroscopic and Structural Studies of New 2-Substituted 4- Nitroimidazoles
Volume: 11 Issue: 3
Author(s): Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Mebarek Bahnous, Thierry Roisnel and Ali Belfaitah
Affiliation:
Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.
Abstract: This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.
Export Options
About this article
Cite this article as:
Alliouche Hayette, Bouraiou Abdelmalek, Bouacida Sofiane, Bahnous Mebarek, Roisnel Thierry and Belfaitah Ali, Synthesis, Spectroscopic and Structural Studies of New 2-Substituted 4- Nitroimidazoles, Letters in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/15701786113106660090
DOI https://dx.doi.org/10.2174/15701786113106660090 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown
Current Medicinal Chemistry NMNAT Expression and its Relation to NAD Metabolism
Current Medicinal Chemistry Role of Immune Cells in Diabetic Kidney Disease
Current Gene Therapy Pteridine Derivatives as Modulators of Oxidative Stress
Current Drug Metabolism Targeted Cancer Immunotherapy Using Ligands of the Tumor Necrosis Factor Super-Family
Current Drug Targets PLA2 Mediated Arachidonate Free Radicals: PLA2 Inhibition and Neutralization of Free Radicals by Anti-Oxidants – A New Role as Anti-Inflammatory Molecule
Current Topics in Medicinal Chemistry Enhancement of Immunoprotective Effect of CpG-ODN by Formulation with Polyphosphazenes Against E. coli Septicemia in Neonatal Chickens
Current Drug Delivery Molecular Players at the Intersection of Obesity and Osteoarthritis
Current Drug Targets A Ferrocene Derivative Reduces Cisplatin Resistance in Breast Cancer Cells through Suppression of MDR-1 Expression and Modulation of JAK2/STAT3 Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry Allergic Contact Dermatitis: Novel Mechanisms and Therapeutic Perspectives
Current Drug Metabolism Inhibitory Smad7: Emerging Roles in Health and Disease
Current Molecular Pharmacology Recent Advances in Gut Nutrient Chemosensing
Current Medicinal Chemistry Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016)
Recent Patents on Anti-Cancer Drug Discovery Endothelial Dysfunction in Diabetes: The Role of Protein Kinase C
Vascular Disease Prevention (Discontinued) Host Restriction Factors and Human Immunodeficiency Virus (HIV-1): A Dynamic Interplay Involving All Phases of the Viral Life Cycle
Current HIV Research Characteristics Other than the Diagnostic Criteria Associated with Metabolic Syndrome: An Overview
Current Vascular Pharmacology A Review of Inadequate and Excessive Weight Gain in Pregnancy
Current Women`s Health Reviews Application of SCR Priming VLP Boosting as a Novel Vaccination Strategy Against HIV-1
Current HIV Research Safety and Efficacy of Tumor-Targeted Interleukin 12 Gene Therapy in Treated and Non-Treated, Metastatic Lesions
Current Gene Therapy Experimental Models of Relapsing-Remitting Multiple Sclerosis: Current Concepts and Perspective
Current Neurovascular Research