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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Combinatorial Synthesis of Benzimidazole-Azo-Phenol Derivatives as Antifungal Agents

Author(s): Yazhen Ke, Xiaoyan Zhi, Xiang Yu, Guodong Ding, Chun Yang and Hui Xu

Volume 17, Issue 1, 2014

Page: [89 - 95] Pages: 7

DOI: 10.2174/13862073113166660058

Price: $65

Abstract

A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively.

Keywords: Antifungal activity, benzimidazole-azo-phenol, phytopathogenic fungi, synthesis.

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