Prospects for Combinatorial Chemistry in the Agrosciences

Stephen   D.   Lindell; Jurgen      Scherkenbeck

doi:10.2174/138620705774575319

Abstract

The recent progress and future prospects for the successful application of combinatorial chemistry and high throughput screening within the agrochemical lead discovery process are outlined and discussed. Solid and solution phase library synthesis technologies are reviewed and compared, and the role and importance of bioavailability, diversity and virtual screening in rational library design are detailed.

Keywords: combinatorial library, bioavailability, diversity, virtual screening, target docking, fragment assembly

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Combinatorial Chemistry & High Throughput Screening

Title: Prospects for Combinatorial Chemistry in the Agrosciences

Volume: 8 Issue: 7

Author(s): Stephen D. Lindell and Jurgen Scherkenbeck

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Keywords: combinatorial library, bioavailability, diversity, virtual screening, target docking, fragment assembly

Abstract: The recent progress and future prospects for the successful application of combinatorial chemistry and high throughput screening within the agrochemical lead discovery process are outlined and discussed. Solid and solution phase library synthesis technologies are reviewed and compared, and the role and importance of bioavailability, diversity and virtual screening in rational library design are detailed.

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Lindell D. Stephen and Scherkenbeck Jurgen, Prospects for Combinatorial Chemistry in the Agrosciences, Combinatorial Chemistry & High Throughput Screening 2005; 8 (7) . https://dx.doi.org/10.2174/138620705774575319