Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

Wang      Liju; Keyume      Ablajan

doi:10.2174/15701794113106660079

Abstract

Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.

Keywords: Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.

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Current Organic Synthesis

Title:Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

Volume: 11 Issue: 2

Author(s): Wang Liju and Keyume Ablajan

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Keywords: Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.

Abstract: Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.

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Liju Wang and Ablajan Keyume, Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives, Current Organic Synthesis 2014; 11 (2) . https://dx.doi.org/10.2174/15701794113106660079