Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence

Title:Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence

Volume: 10 Issue: 4

Author(s): Stefania Schiavone, Marilena Colaianna and Luigia Trabace

Affiliation:

Keywords: Amphetamine, central nervous system, cocaine, GHB, heroin, marijuana, NMDA-antagonists, oxidative stress.

Abstract: Several studies have attempted to clarify molecular pathways leading to drug addiction. Increased reactive oxygen species production in the central nervous system has been recently proposed to play a pivotal role in the neuropathology induced by drug abuse. In this review, we summarize current knowledge on the involvement of oxidative stress in the development of neural dysfunctions induced by prolonged exposure to specific drugs of abuse: N-methyl-D-aspartate receptor antagonists (ketamine, phencyclidine and dizocilpine maleate), cocaine, heroin, marijuana, gammahydroxybutyrate, amphetamine and methamphetamine. Understanding the role of increased oxidative damage in the central nervous system following abuse of these compounds may provide original molecular perspectives leading to innovative therapeutic strategies.

Cite this article as:

Schiavone Stefania, Colaianna Marilena and Trabace Luigia, Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence, Mini-Reviews in Organic Chemistry 2013; 10 (4) . https://dx.doi.org/10.2174/1570193X113106660030