Prion Chemical Biology: On the Road to Therapeutics?

Beining      Chen; Mark      Thompson; Jennifer      Louth; Kai      Guo

doi:10.2174/15680266113136660172

Abstract

Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.

Keywords: Quinacrine, antiprion, prion protein, drug discovery, indole, prion diseases, pyridine dicarbonitrile, thiazole.

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