Abstract
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are discussed.
Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.
CNS & Neurological Disorders - Drug Targets
Title:Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus
Volume: 13 Issue: 2
Author(s): Rizwanul Haque and Aamir Nazir
Affiliation:
Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.
Abstract: Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are discussed.
Export Options
About this article
Cite this article as:
Haque Rizwanul and Nazir Aamir, Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus, CNS & Neurological Disorders - Drug Targets 2014; 13 (2) . https://dx.doi.org/10.2174/18715273113126660139
DOI https://dx.doi.org/10.2174/18715273113126660139 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antidiabetic Oils
Current Diabetes Reviews Systemic Sclerosis: Clinical Manifestations
Current Rheumatology Reviews Intra-uterine Growth Retardation as a Risk Factor of Postnatal Metabolic Disorders
Current Pharmaceutical Biotechnology Recombinant Activated Factor VII as a General Haemostatic Agent:Evidence-Based Efficacy and Safety
Current Drug Safety Homocysteine in Neurology: From Endothelium to Neurodegeneration
Current Nutrition & Food Science Influence of Ultrasound Mediated Transdermal Delivery of Losartan Potassium
Drug Delivery Letters Synergy of microRNA and Stem Cell: A Novel Therapeutic Approach for Diabetes Mellitus and Cardiovascular Diseases
Current Diabetes Reviews Recent Advances in the Management of Pulmonary Arterial Hypertension
Current Respiratory Medicine Reviews Strategies for Enhancing Progenitor Cell Mobilization and Function in Diabetes
Current Vascular Pharmacology Renal Nerve Ablation for Hypertensive Patients with Chronic Kidney Disease
Current Vascular Pharmacology Growth Restriction: Etiology, Maternal and Neonatal Outcome. A Review
Current Women`s Health Reviews Hypoxia in Pre-Eclampsia: Cause or Effect?
Current Women`s Health Reviews MicroRNA Therapeutics for Cardiac Regeneration
Mini-Reviews in Medicinal Chemistry Demystifying the ACE Polymorphism: From Genetics to Biology
Current Pharmaceutical Design Editorial (Thematic Issue: Calcium in Heart Disease: The Ubiquitous Ion)
Medicinal Chemistry The Genetics of Small-Vessel Disease
Current Medicinal Chemistry Aldosterone Receptor Antagonists and Cardiovascular Disease: Do We Need a Change of the Guard?
Cardiovascular & Hematological Agents in Medicinal Chemistry Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies
Current Medicinal Chemistry NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects
Current Topics in Medicinal Chemistry Noscapine-loaded PLA Nanoparticles: Systematic Study of Effect of Formulation and Process Variables on Particle Size, Drug Loading and Entrapment Efficiency
Pharmaceutical Nanotechnology