Synaptic Dysfunction in Synucleinopathies

Title:Synaptic Dysfunction in Synucleinopathies

Volume: 12 Issue: 8

Author(s): Oleg Anichtchik, Laura Calo and Maria Grazia Spillantini

Affiliation:

Keywords: Synaptic dysfunction, synucleinopathies, neurodegenerative disorders, animal models, Alzheimer’s disease, central nervous system, dementia, Lewy body.

Abstract: Pathological aggregation of alpha-synuclein as Lewy-bodies and neurites is a hallmark of a group of neurodegenerative disorders named alpha-synucleinopathies. It is becoming apparent that alpha-synuclein facilitates presynaptic neuronal function in the brain, and events leading to its aggregation produce marked disruption of neurotransmitter release mechanism. We discuss here the literature related to the function of alpha-synuclein at the neuronal synapse in synucleinopathies brains and corresponding animal models.

Cite this article as:

Anichtchik Oleg, Calo Laura and Spillantini Grazia Maria, Synaptic Dysfunction in Synucleinopathies, CNS & Neurological Disorders - Drug Targets 2013; 12 (8) . https://dx.doi.org/10.2174/18715273113129990114