Synaptic Dysfunction in Synucleinopathies

Oleg      Anichtchik; Laura      Calo; Maria   Grazia   Spillantini

doi:10.2174/18715273113129990114

Abstract

Pathological aggregation of alpha-synuclein as Lewy-bodies and neurites is a hallmark of a group of neurodegenerative disorders named alpha-synucleinopathies. It is becoming apparent that alpha-synuclein facilitates presynaptic neuronal function in the brain, and events leading to its aggregation produce marked disruption of neurotransmitter release mechanism. We discuss here the literature related to the function of alpha-synuclein at the neuronal synapse in synucleinopathies brains and corresponding animal models.

Keywords: Synaptic dysfunction, synucleinopathies, neurodegenerative disorders, animal models, Alzheimer’s disease, central nervous system, dementia, Lewy body.