Abstract
Atherosclerosis remains one of the main causes of cardiovascular disease, which is the leading cause of death worldwide. It is now accepted that atherosclerosis is an inflammatory, dynamic and complex disease involving multiple cell types, and many antiinflammatory strategies have recently emerged as potential therapeutic approaches for atherosclerotic disease. In this review, we discuss the most recent progress in the development of anti-inflammatory strategies. We highlight the beneficial effects of potent antiinflammatory drugs, including recently developed biologics, and we describe diverse emerging approaches that target inflammatory processes involved in atherosclerosis including tumor necrosis factor antagonists, anti-interleukins, viral-derived serpins, P-selectin inhibition and leukotriene synthesis inhibition.
Keywords: Atherosclerosis, coronary disease, inflammation, interleukin-1, serpins, Tumor Necrosis Factor alpha, leukotriene, P-selectin, colchicine.
Current Pharmaceutical Design
Title:Emerging Anti-inflammatory Therapies for Atherosclerosis
Volume: 19 Issue: 33
Author(s): François Roubille, Ekaterini A. Kritikou, Camille Roubille and Jean-Claude Tardif
Affiliation:
Keywords: Atherosclerosis, coronary disease, inflammation, interleukin-1, serpins, Tumor Necrosis Factor alpha, leukotriene, P-selectin, colchicine.
Abstract: Atherosclerosis remains one of the main causes of cardiovascular disease, which is the leading cause of death worldwide. It is now accepted that atherosclerosis is an inflammatory, dynamic and complex disease involving multiple cell types, and many antiinflammatory strategies have recently emerged as potential therapeutic approaches for atherosclerotic disease. In this review, we discuss the most recent progress in the development of anti-inflammatory strategies. We highlight the beneficial effects of potent antiinflammatory drugs, including recently developed biologics, and we describe diverse emerging approaches that target inflammatory processes involved in atherosclerosis including tumor necrosis factor antagonists, anti-interleukins, viral-derived serpins, P-selectin inhibition and leukotriene synthesis inhibition.
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Cite this article as:
Roubille François, Kritikou A. Ekaterini, Roubille Camille and Tardif Jean-Claude, Emerging Anti-inflammatory Therapies for Atherosclerosis, Current Pharmaceutical Design 2013; 19 (33) . https://dx.doi.org/10.2174/13816128113199990351
DOI https://dx.doi.org/10.2174/13816128113199990351 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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