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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Indium(III) Catalyzed Direct sp3-sp C-C Bond Formation from Alcohols and Terminal Alkynes

Author(s): Guangming Nan and Jun Zhou

Volume 10, Issue 8, 2013

Page: [555 - 561] Pages: 7

DOI: 10.2174/1570178611310080004

Price: $65

Abstract

A simple and efficient indium(III)-catalyzed sp3-sp C-C bond formation reaction via direct coupling of alcohols with terminal alkynes has been developed under mild conditions without any ligand, base or additive, in which both of aromatic and aliphatic alkynes and various alcohols such as benzylic, allylic and propargylic alcohols can be tolerated. This simple reaction system provides an attractive approach to a large number of internal alkynes in moderate to good yields, and only generates H2O as the side product.

Keywords: sp3-sp C-C bond, alkynes, alcohols, indium(III) salts, catalytic synthesis, coupling reaction.


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