摘要
目的:本研究的目的是分析重庆市中国老年人群阿尔茨海默病(AD)与骨质疏松症的风险之间的关系。 方法:2007年6月至2013年1月间对60- 75岁的1802例患者进行了6年的随访的前瞻性研究。用双能X线骨密度仪来评估骨密度(BMD)。采用简易精神状态检查量表(MMSE)中文版和日常生活活动(ADL)的检测工具检测认知功能。Cox比例风险模型被用于检测AD和骨质疏松的风险之间的关联。 结果:调整了年龄、女性、AD,25-羟基维生素D(25(OH)D)、吸烟、饮酒与中风,AD(风险比,HR 2.48,95% CI 1.66-2.94)、年龄(HR 1.36,95% CI 1.14-1.60)、女性(HR 1.39,95% CI 1.17-1.65)、25(OH)D(HR 1.34,95% CI 1.11-1.59)、目前吸烟(HR 1.27,95% CI 1.22-1.43),每天饮酒(HR 1.33,95% CI 1.11-1.52)和中风(HR 1.26,95% CI 1.14-1.58)与骨质疏松症的风险增加有关。在骨质疏松性骨折组中,AD的骨质疏松症比认知功能的正常的骨质疏松症更常见。 结论:中国重庆老年人群AD与骨质疏松症的风险增加有关。
关键词: 阿尔茨海默病,痴呆症,雌激素,骨折,高胆固醇血症,骨质疏松症。
Current Alzheimer Research
Title:Alzheimer’s Disease is Associated with Increased Risk of Osteoporosis: The Chongqing Aging Study
Volume: 13 Issue: 10
Author(s): Dong Liu, Huadong Zhou, Yong Tao, Jun Tan, Lin Chen, Haiyang Huang, Yang Chen, Yafei Li, Rui Zhou
Affiliation:
关键词: 阿尔茨海默病,痴呆症,雌激素,骨折,高胆固醇血症,骨质疏松症。
摘要: Objective: The aim of this study was to analyze the relationship between Alzheimer’s disease (AD) and a risk of osteoporosis in the elderly cohort of Chongqing, China.
Methods: A prospective study with 6 years of follow-up in 1802 patients aged 60– 75 was conducted from January 2007 to June 2013. Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density (BMD). Their cognitive function was detected using the Chinese version of the Mini-Mental State Examination (MMSE) and a detection of the instrumental activities of daily living (ADL). Cox proportional hazards models were used to detect the association between AD and the risk of osteoporosis.
Results: After adjusting for age, female, AD, 25-hydroxyvitamine D (25(OH)D), smoking, drinking and stroke, AD (Hazard ratio, HR 2.48, 95%CI 1.66-2.94), age (HR 1.36, 95% CI 1.14-1.60), female (HR 1.39, 95% CI 1.17-1.65), 25(OH)D (HR1.34, 95%CI 1.11-1.59), current smoking (HR 1.27, 95%CI 1.22-1.43), daily drinking (HR 1.33, 95%CI 1.11-1.52) and stroke (HR 1.26, 95%CI 1.14-1.58) were associated with increased risk of osteoporosis. In osteoporosis fracture group, osteoporosis with AD was more common than osteoporosis with normal cognition function.
Conclusion: AD was associated with an increased risk of osteoporosis in the elderly cohort of Chongqing, China.
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Cite this article as:
Dong Liu, Huadong Zhou, Yong Tao, Jun Tan, Lin Chen, Haiyang Huang, Yang Chen, Yafei Li, Rui Zhou , Alzheimer’s Disease is Associated with Increased Risk of Osteoporosis: The Chongqing Aging Study, Current Alzheimer Research 2016; 13 (10) . https://dx.doi.org/10.2174/15672050113109990149
DOI https://dx.doi.org/10.2174/15672050113109990149 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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