Abstract
Although proteomics is a very recently developed science, important advances have already occurred in this field. There is growing interest in the scientific community for using this technology as a high-throughput innovative strategy for biomarker discovery in the field of cancer research. However, certain challenges must be overcome before reaching this goal. The basis for discovering reliable biomarkers is rooted in technical and biological parameters. The main biological limit is outlining tumor heterogeneity, while methodological issues include appropriate study designs, the use of sensitive technologies for screening, and the employment of confident strategies for data validation. This review focuses on the major questions related to the strengths and limitations of the development of cancer biomarkers by proteomic- based studies.
Keywords: Biomarkers, cancer, design of studies, mass spectrometry, proteomics, tumor heterogeneity.
Current Proteomics
Title:How can Proteomics Reach Cancer Biomarkers?
Volume: 10 Issue: 2
Author(s): Carolina Panis, Luciana Pizzatti and Eliana Abdelhay
Affiliation:
Keywords: Biomarkers, cancer, design of studies, mass spectrometry, proteomics, tumor heterogeneity.
Abstract: Although proteomics is a very recently developed science, important advances have already occurred in this field. There is growing interest in the scientific community for using this technology as a high-throughput innovative strategy for biomarker discovery in the field of cancer research. However, certain challenges must be overcome before reaching this goal. The basis for discovering reliable biomarkers is rooted in technical and biological parameters. The main biological limit is outlining tumor heterogeneity, while methodological issues include appropriate study designs, the use of sensitive technologies for screening, and the employment of confident strategies for data validation. This review focuses on the major questions related to the strengths and limitations of the development of cancer biomarkers by proteomic- based studies.
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Cite this article as:
Panis Carolina, Pizzatti Luciana and Abdelhay Eliana, How can Proteomics Reach Cancer Biomarkers?, Current Proteomics 2013; 10 (2) . https://dx.doi.org/10.2174/1570164611310020006
DOI https://dx.doi.org/10.2174/1570164611310020006 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
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