Abstract
Renal sympathetic innervation plays an important role in blood pressure regulation. Gradual activation of renal sympathetic efferent nerves enhances renin release, promotes sodium and water re-absorption, and reduces renal blood flow and glomerular filtration rate. On the other hand, activation of renal afferent sympathetic nerves induced by renal injury results in central sympathetic activation. This reciprocal relationship between the kidneys and the brain is involved in the pathogenesis of hypertension and other disease conditions characterized by sympathetic overactivity. Renal sympathetic nerve ablation has been recently introduced for the treatment of resistant hypertension. This review aims to provide the pathophysiological basis of renal nerve ablation for the attenuation of sympathetic overactivity.
Keywords: Renal nerve ablation, renal sympathetic denervation, anatomy, physiology, efferent renal sympathetic nerves, afferent renal sympathetic nerves, renin, sodium reabsorption, renal blood flow, glomerular filtration rate.
Current Vascular Pharmacology
Title:The Pathophysiological Basis of Renal Nerve Ablation for the Treatment of Hypertension
Volume: 12 Issue: 1
Author(s): Ziakas A., Gossios T., Doumas M., Karali K., Megarisiotou A. and Stiliadis I.
Affiliation:
Keywords: Renal nerve ablation, renal sympathetic denervation, anatomy, physiology, efferent renal sympathetic nerves, afferent renal sympathetic nerves, renin, sodium reabsorption, renal blood flow, glomerular filtration rate.
Abstract: Renal sympathetic innervation plays an important role in blood pressure regulation. Gradual activation of renal sympathetic efferent nerves enhances renin release, promotes sodium and water re-absorption, and reduces renal blood flow and glomerular filtration rate. On the other hand, activation of renal afferent sympathetic nerves induced by renal injury results in central sympathetic activation. This reciprocal relationship between the kidneys and the brain is involved in the pathogenesis of hypertension and other disease conditions characterized by sympathetic overactivity. Renal sympathetic nerve ablation has been recently introduced for the treatment of resistant hypertension. This review aims to provide the pathophysiological basis of renal nerve ablation for the attenuation of sympathetic overactivity.
Export Options
About this article
Cite this article as:
A. Ziakas, T. Gossios, M. Doumas, K. Karali, A. Megarisiotou and I. Stiliadis, The Pathophysiological Basis of Renal Nerve Ablation for the Treatment of Hypertension, Current Vascular Pharmacology 2014; 12 (1) . https://dx.doi.org/10.2174/15701611113119990145
DOI https://dx.doi.org/10.2174/15701611113119990145 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Brain Perfusion In Sepsis
Current Vascular Pharmacology Optical Techniques in the Assessment of Peripheral Arterial Disease
Current Vascular Pharmacology Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus
Current Diabetes Reviews Editorial (Thematic Issue: The (Same Old) Problem of Uncontrolled Hypertension)
Current Hypertension Reviews Perivascular Adipose Tissue, Inflammation and Vascular Dysfunction in Obesity
Current Vascular Pharmacology Educating Scientists in Translational and Entrepreneurial Medicine: Unmet Needs and Challenges
Technology Transfer and Entrepreneurship (Discontinued) Editorial [Hot Topic: Gout (Guest Editor: Tony R. Merriman)]
Current Rheumatology Reviews Radziszewski Reaction: An Elegant, Easy, Simple and Efficient Method to Synthesise Imidazoles
Current Organic Synthesis Endothelium Dependent and Independent Mechanisms of Vasorelaxant Activity of Synthesized 2,5-disubstituted-1,3,4-oxadiazole Derivatives in Rat Thoracic Aorta – Ex vivo and Molecular Docking Studies
Letters in Drug Design & Discovery Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents
Current Topics in Medicinal Chemistry The Biological and Clinical Activity of Anti-Malarial Drugs In Autoimmune Disorders
Current Rheumatology Reviews Heart Failure in the Middle East
Current Cardiology Reviews Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds
Current Organocatalysis Patent Selections
Recent Patents on DNA & Gene Sequences Recent Advances on Nitric Oxide in the Upper Airways
Current Medicinal Chemistry Lead (Pb) in Alzheimer’s Dementia: A Systematic Review of Human Case- Control Studies
Current Alzheimer Research Post-stroke Depression Therapy: Where are we now?
Current Neurovascular Research L-Arginine Availability as a Pathological Mechanism in Essential Hypertension, Chronic Renal and Heart Failure
Vascular Disease Prevention (Discontinued) Integrating Care for Older Adults with Cognitive Impairment
Current Alzheimer Research Microvesicles-mediated Cell Communication in Pulmonary Arterial Hypertension
Current Medicinal Chemistry