Abstract
An account of our development of the Pot, Atom and Step Economic (PASE) synthesis of tetrahydropyrans, dihydropyrans and piperidines, based on the Maitland-Japp reaction is given. The value of these reactions as a strategy in natural product synthesis is highlighted and recent further developments of the PASE syntheses in the literature is reported.
Keywords: Dihydropyrans, Multi-component, PASE, Piperidines, Tetrahydropyrans.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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