Tamoxifen Citrate Loaded Ethosomes for Transdermal Drug Delivery System: Preparation and Characterization

Title:Tamoxifen Citrate Loaded Ethosomes for Transdermal Drug Delivery System: Preparation and Characterization

Volume: 10 Issue: 4

Author(s): Khomendra Kumar Sarwa, Preeti K Suresh, Manabendra Debnath and Mohammad Zaki Ahmad

Affiliation:

Keywords: Tamoxifen Citrate, Ethosomes, Liposomes, Transdermal, Skin.

Abstract: Long term tamoxifen citrate therapy is imperative to treat several dermatological and hormonal sensitive disorders. Successful oral and parenteral administration of tamoxifen citrate has been challenging since it undergoes enzymatic degradation and has poor aqueous solubility issues. In the present work, tamoxifen citrate loaded ethosomes were prepared and characterized for transdermal applications. The prepared formulations were characterized for morphological features, particle size distribution, calorimetric attributes, zeta potential and drug entrapment. Permeation profile of prepared ethosomes was compared with liposomes and hydroethonalic solution across cellophane membrane and human cadaver skin. Results of the permeation studies indicate that ethosomes were able to deliver >90% drug within 24 hours of application, while liposomes and hydroethanolic solution delivered only 39.04% and 36.55% respectively. Skin deposition and stability studies are also reported.

Cite this article as:

Sarwa Kumar Khomendra, Suresh K Preeti, Debnath Manabendra and Ahmad Zaki Mohammad, Tamoxifen Citrate Loaded Ethosomes for Transdermal Drug Delivery System: Preparation and Characterization, Current Drug Delivery 2013; 10 (4) . https://dx.doi.org/10.2174/1567201811310040011