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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis

Author(s): Yisha Yao, Yang Yang and Wei-Guo Zhu

Volume 20, Issue 11, 2014

Page: [1614 - 1624] Pages: 11

DOI: 10.2174/13816128113199990513

Price: $65

Abstract

Sir2-like proteins, known as sirtuins, have been under a spotlight in the realm of aging because of their positive effect on longevity in Saccharomyces.cerevisiae. Because Sir2 has been identified as a NAD+-dependent histone deacetylase, researchers have attributed its lifespan-extending utilities to gene silencing. Similar phenomena are found in multicellular eukaryotes by seemingly different mechanisms. In mammals, seven sirtuin homologs (SIRT1-7) have been identified, with varied cellular locations and molecular functions. Sirtuins target a wide spectrum of molecules for diversified post-translational modifications, thereby exerting multiple physiological benefits. The roles of sirtuins in cancer are still ambiguous, although they have been extensively studied. In this review, we summarize the multiple physiological roles played by sirtuins and their putative mechanisms, especially in cancer.

Keywords: Sirtuin, post-translational modification, aging, metabolism, genomic stability, apoptosis, autophagy.


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