Abstract
Indirect resolution of chiral molecules, based upon pre-column derivatization and diastereomer formation using benzofurazan bearing chiral labeling reagents, by high-performance liquid chromatography are described in this minireview. The synthesis, characteristics and application of the fluorescent chiral derivatization reagents for various functional groups, i.e. amine (NBD-PyNCS, DBD-PyNCS, DBD-β-Pro, DBD-hydroxyproline), carboxyl (NBD-APy, DBD-APy, ABD-APy), carbonyl (NBD-ProCZ, DBD-ProCZ), hydroxyl (NBD-Pro-COCl, DBD-Pro-COCl) and thiol, etc., are including in the text.
Keywords: benzofurazan fluorophore, chiral resolution, biological important molecule, diastereomer formation, hplc analysis
Related Journals
Related Books
New Findings from Natural Substances
Pharmaceutical Chemistry and Production: An Introductory Textbook
Evidence-Based Research in Ayurveda against COVID-19 in Compliance with Standardized Protocols and Practices
Pharmaceuticals for Targeting Coronaviruses
Medical Applications of Beta-Glucan
Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application
Postbiotics: Science, Technology and Applications
Biologically Active Natural Products from Asia and Africa: A Selection of Topics
13