Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives

Title:Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives

Volume: 9 Issue: 4

Author(s): Javad Azizian, Ehsan Ardestani and Mahdieh Entezari

Affiliation:

Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.

Abstract: In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed.

Cite this article as:

Azizian Javad, Ardestani Ehsan and Entezari Mahdieh, Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives, Current Nanoscience 2013; 9 (4) . https://dx.doi.org/10.2174/1573413711309040004