Abstract
Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.
Keywords: Anticancer, cancer, prodrug, small molecule, therapy.
Anti-Cancer Agents in Medicinal Chemistry
Title:Recent Advances in Small Molecule Prodrugs for Cancer Therapy
Volume: 14 Issue: 3
Author(s): Peng Wang, Xiao Jin, Jin Cai, Junqing Chen and Min Ji
Affiliation:
Keywords: Anticancer, cancer, prodrug, small molecule, therapy.
Abstract: Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.
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Cite this article as:
Wang Peng, Jin Xiao, Cai Jin, Chen Junqing and Ji Min, Recent Advances in Small Molecule Prodrugs for Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (3) . https://dx.doi.org/10.2174/18715206113139990317
DOI https://dx.doi.org/10.2174/18715206113139990317 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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