Abstract
Micro-reaction technology is entering more and more into chemical process engineering and chemistry, complementing existing technologies. The benefits of microstructured reactors such as enhanced mass and heat transfer, defined residence time setting, and known, highly regular flow profiles give process intensification following standard chemical protocols. These unique features, however, can achieve more, namely to enable process chemistry with novel features. This includes handling of instable intermediates, safe processing in the explosive regime, setting reaction temperature at unusually high level, and more. In this way, the engineering benefits change the chemistry; thus, it has been termed novel chemistry here. While this has been done in a heuristic manner in the past, first deductive approaches were recently developed based on diffusion-reaction calculations and potential energy profiles which provide a mechanistic understanding what the new tool can do. In this context, many examples for organic reactions in microstructured reactors are described to underline the possible means of novel chemistry by using microstructured reactors.
Keywords: microstructuring techniques, microfluidic, reactors, micro-reactor-process design, impinging-jet reactors, mechanistic chain quenching, stemming, sonogashira coupling, mizoroki-heck reaction, suzuki coupling
Current Organic Chemistry
Title: Development of Microstructured Reactors to Enable Organic Synthesis Rather than Subduing Chemistry
Volume: 9 Issue: 8
Author(s): Volker Hessel, Patrick Lob and Holger Lowe
Affiliation:
Keywords: microstructuring techniques, microfluidic, reactors, micro-reactor-process design, impinging-jet reactors, mechanistic chain quenching, stemming, sonogashira coupling, mizoroki-heck reaction, suzuki coupling
Abstract: Micro-reaction technology is entering more and more into chemical process engineering and chemistry, complementing existing technologies. The benefits of microstructured reactors such as enhanced mass and heat transfer, defined residence time setting, and known, highly regular flow profiles give process intensification following standard chemical protocols. These unique features, however, can achieve more, namely to enable process chemistry with novel features. This includes handling of instable intermediates, safe processing in the explosive regime, setting reaction temperature at unusually high level, and more. In this way, the engineering benefits change the chemistry; thus, it has been termed novel chemistry here. While this has been done in a heuristic manner in the past, first deductive approaches were recently developed based on diffusion-reaction calculations and potential energy profiles which provide a mechanistic understanding what the new tool can do. In this context, many examples for organic reactions in microstructured reactors are described to underline the possible means of novel chemistry by using microstructured reactors.
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Cite this article as:
Hessel Volker, Lob Patrick and Lowe Holger, Development of Microstructured Reactors to Enable Organic Synthesis Rather than Subduing Chemistry, Current Organic Chemistry 2005; 9 (8) . https://dx.doi.org/10.2174/1385272053764953
DOI https://dx.doi.org/10.2174/1385272053764953 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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