Abstract
A series of norbornane containing amphiphiles was synthesized, their lipophilicity corresponding to neutral and cationic forms was then investigated using reverse phase HPLC (High Performance Liquid Chromatography). This series of amphiphiles incorporated varied lipophilic chain length and also varied distances between the polar/cationic head group from the norbornane scaffold. Our investigation included studying the impact of the stationary phase as a replication of a membrane for both cationic and neutral amphiphiles. The choice of stationary phase was shown to be a very important consideration for this type of measurement. In this connection, C18, Cyano and Polar columns were all investigated, the cyano column was observed to be the optimal stationary phase for the comparison of both charged and neutral amphiphiles.
Keywords: Amphiphiles, cationic lipid, capacity factor, lipophilicity, high performance liquid chromatography.
Current Analytical Chemistry
Title:Synthesis and Comparative Physical-chemical Characterisation of Neutral and Cationic Amphiphiles Using RP-HPLC
Volume: 9 Issue: 4
Author(s): Jennifer S. Squire, Luke C. Henderson and Xavier A. Conlan
Affiliation:
Keywords: Amphiphiles, cationic lipid, capacity factor, lipophilicity, high performance liquid chromatography.
Abstract: A series of norbornane containing amphiphiles was synthesized, their lipophilicity corresponding to neutral and cationic forms was then investigated using reverse phase HPLC (High Performance Liquid Chromatography). This series of amphiphiles incorporated varied lipophilic chain length and also varied distances between the polar/cationic head group from the norbornane scaffold. Our investigation included studying the impact of the stationary phase as a replication of a membrane for both cationic and neutral amphiphiles. The choice of stationary phase was shown to be a very important consideration for this type of measurement. In this connection, C18, Cyano and Polar columns were all investigated, the cyano column was observed to be the optimal stationary phase for the comparison of both charged and neutral amphiphiles.
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Cite this article as:
Squire S. Jennifer, Henderson C. Luke and Conlan A. Xavier, Synthesis and Comparative Physical-chemical Characterisation of Neutral and Cationic Amphiphiles Using RP-HPLC, Current Analytical Chemistry 2013; 9 (4) . https://dx.doi.org/10.2174/1573411011309040016
DOI https://dx.doi.org/10.2174/1573411011309040016 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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