Recent Developments in the Identification of Chemotherapeutics for Chagas Disease

Title: Recent Developments in the Identification of Chemotherapeutics for Chagas Disease

Volume: 12 Issue: 8

Author(s): Jeffrey W. Lockman and Andrew D. Hamilton

Affiliation:

Keywords: parasitic disease, trypanosoma cruzi, autoimmunity, proinflammatory, t cells, chemotherapeutics, gycolysis, glyceraldehyde-3-phosphate dehydrogenase (gadph)

Abstract: Chagas Disease, caused by the T. cruzi parasite, is one of the largest public health problems in the Western hemisphere. Although its spread has diminished due to vector eradication programs, effective chemotherapeutics for the disease itself remain elusive. Many efforts towards the development of antiparasitic agents active against a number of targets have been described recently in the literature. This review summarizes developments in trypanosidal agents from 2000 through 2003.

Cite this article as:

Lockman W. Jeffrey and Hamilton D. Andrew, Recent Developments in the Identification of Chemotherapeutics for Chagas Disease, Current Medicinal Chemistry 2005; 12 (8) . https://dx.doi.org/10.2174/0929867053507289