Abstract
Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the catalytic conversion of angiotensinogen (AGT) to angiotensin (Ang) I. This binding also transduces intracellular signal to the nucleus via various pathways. Our recent research elucidated the physiological roles of (P)RR in cell life, wherein it acts as an essential accessory protein of vacuolar H+-ATPase (V-ATPase) as well as an adaptor protein of Wnt signaling. The present review provides insights into a novel approach to cardiovascular diseases, which will open the gates to new therapeutic approaches for treating cardiovascular diseases.
Keywords: (Pro)renin receptor, vascuolar H+-ATPase, direct renin inhibitor.
Current Pharmaceutical Design
Title:Novel Approach to Cardiovascular Diseases: A Promising Probability of (Pro)Renin Receptor [(P)RR]
Volume: 20 Issue: 14
Author(s): Takashi Ando and Atsuhiro Ichihara
Affiliation:
Keywords: (Pro)renin receptor, vascuolar H+-ATPase, direct renin inhibitor.
Abstract: Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the catalytic conversion of angiotensinogen (AGT) to angiotensin (Ang) I. This binding also transduces intracellular signal to the nucleus via various pathways. Our recent research elucidated the physiological roles of (P)RR in cell life, wherein it acts as an essential accessory protein of vacuolar H+-ATPase (V-ATPase) as well as an adaptor protein of Wnt signaling. The present review provides insights into a novel approach to cardiovascular diseases, which will open the gates to new therapeutic approaches for treating cardiovascular diseases.
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Cite this article as:
Ando Takashi and Ichihara Atsuhiro, Novel Approach to Cardiovascular Diseases: A Promising Probability of (Pro)Renin Receptor [(P)RR], Current Pharmaceutical Design 2014; 20 (14) . https://dx.doi.org/10.2174/13816128113199990472
DOI https://dx.doi.org/10.2174/13816128113199990472 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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