Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

Title:Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

Volume: 10 Issue: 2

Author(s): Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang

Affiliation:

Keywords: Enantioseparation, propranolol, β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography.

Abstract: Extremely good enantioseparation of a kind of commonly used β-blockers, (±)-propranolol, has been achieved on silica gel layers which were impregnated with β-cyclodextrin and oxidized multi-walled carbon nanotubes. Solvent system tert-butenol-acetonitrile (1:1, v/v) successfully resolved the enantiomers of (±)-propranolol. The spots were detected at 254 nm with a UV lamp. The effect of concentration of the mobile phase variation was also studied.

Cite this article as:

Chen Xiao-Qing, Sun Cong-Hao, Jiao Fei-Peng, Yu Jin-Gang and Jiang Xin-Yu, Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography, Current Analytical Chemistry 2014; 10 (2) . https://dx.doi.org/10.2174/15734110113090990028