Abstract
This paper gives an overview of the available methods for racemization of amines and related derivatives, and the racemization catalysts can be coupled with enzymes to achieve the dynamic kinetic resolution, which provides enantiopure products with approximate 100% yields. Transition metal-catalyzed racemization, free radical-based racemization, racemase leading to automatic racemization and alkali-catalyzed racemization have been summarized, and their advantages and disadvantages have been discussed and compared. A purely enzymatic method would enable efficient and environmentally benign processes as a green and sustainable technique.
Keywords: Racemization, Amines, Enzymes, Dynamic kinetic resolution.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
26