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Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

Author(s): Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony and Ahmed A. M. El-Reedy

Volume 9, Issue 2, 2013

Page: [167 - 181] Pages: 15

DOI: 10.2174/15734072113099990011

Price: $65

Abstract

A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.

Keywords: Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.


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