Amidine-Based Bioactive Compounds for the Regulation of Arginine Metabolism

Title:Amidine-Based Bioactive Compounds for the Regulation of Arginine Metabolism

Volume: 13 Issue: 9

Author(s): Cristina Maccallini, Marialuigia Fantacuzzi and Rosa Amoroso

Affiliation:

Keywords: Nitric oxide synthase (NOS), dimethylarginine dimethylaminohydrolase (DDAH), peptidylarginine deiminase (PAD), amidines.

Abstract: In the research of new bioactive compounds able to regulate the L-arginine metabolism, several substituted amidines were disclosed as potent and selective inhibitors of mainly three enzyme families: the nitric oxide synthase, the dimethylarginine dimethylaminohydrolase and the peptidylarginine deiminase. The present work is focused on the last five years developments in the research for amidine-based inhibitors of the mentioned enzymes and on their potential usefulness in neurodegenerative, inflammatory and autoimmune disorders.

Cite this article as:

Maccallini Cristina, Fantacuzzi Marialuigia and Amoroso Rosa, Amidine-Based Bioactive Compounds for the Regulation of Arginine Metabolism, Mini-Reviews in Medicinal Chemistry 2013; 13 (9) . https://dx.doi.org/10.2174/1389557511313090005