Abstract
The discovery of phosphodiesterase 10A (PDE10A) enzyme ligands as therapeutic agents in the treatment of central nervous system diseases, especially schizophrenia and Huntington’s disease nowadays is a competitive field developing rapidly, with many pharmaceutical companies involved in identifying a huge diversity of chemical scaffolds and molecular architectures for PDE10A interaction. Owing to the importance of this field, the aim of this review is to survey the chemistry and biological properties of linear and angular tricyclic-based heterocycles incorporating valid pharmacophores for PDE10A activity.
Keywords: Linear and angular tricyclic-based heterocycles, synthetic procedures, PDE10A activity.
Mini-Reviews in Organic Chemistry
Title:Chemistry of Tricyclic-based Heterocycles as Useful Scaffolds for Phosphodiesterase 10A Ligands
Volume: 10 Issue: 2
Author(s): Battistina Asproni, Antonio Dore, Gabriele Murineddu and Gerard Aime Pinna
Affiliation:
Keywords: Linear and angular tricyclic-based heterocycles, synthetic procedures, PDE10A activity.
Abstract: The discovery of phosphodiesterase 10A (PDE10A) enzyme ligands as therapeutic agents in the treatment of central nervous system diseases, especially schizophrenia and Huntington’s disease nowadays is a competitive field developing rapidly, with many pharmaceutical companies involved in identifying a huge diversity of chemical scaffolds and molecular architectures for PDE10A interaction. Owing to the importance of this field, the aim of this review is to survey the chemistry and biological properties of linear and angular tricyclic-based heterocycles incorporating valid pharmacophores for PDE10A activity.
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Cite this article as:
Asproni Battistina, Dore Antonio, Murineddu Gabriele and Pinna Aime Gerard, Chemistry of Tricyclic-based Heterocycles as Useful Scaffolds for Phosphodiesterase 10A Ligands, Mini-Reviews in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570193X11310020003
DOI https://dx.doi.org/10.2174/1570193X11310020003 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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