Catalyst-free Alkylation of Aromatic Amines with Aldehydes

Qi      He; Zhouyu      Wang; Shan      Qian; Zhenju      Jiang; Jianhui      Li; Dehong      Jiang; Wensi      Ai

doi:10.2174/1570178611310050012

Abstract

In the absence of any additional catalysts, a series of aromatic amines were alkylated with a range of aromatic and aliphatic aldehydes. Moderate to excellent isolated yields (up to 94%) were obtained under mild conditions. Simultaneously, the reaction time dramatically shortened from hours to minutes when the Microwave technique was used.

Keywords: Catalyst-free, reductive amination, aldehydes, Hantzsch ester.

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Letters in Organic Chemistry

Title:Catalyst-free Alkylation of Aromatic Amines with Aldehydes

Volume: 10 Issue: 5

Author(s): Qi He, Zhouyu Wang, Shan Qian, Zhenju Jiang, Jianhui Li, Dehong Jiang and Wensi Ai

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Keywords: Catalyst-free, reductive amination, aldehydes, Hantzsch ester.

Abstract: In the absence of any additional catalysts, a series of aromatic amines were alkylated with a range of aromatic and aliphatic aldehydes. Moderate to excellent isolated yields (up to 94%) were obtained under mild conditions. Simultaneously, the reaction time dramatically shortened from hours to minutes when the Microwave technique was used.

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He Qi, Wang Zhouyu, Qian Shan, Jiang Zhenju, Li Jianhui, Jiang Dehong and Ai Wensi, Catalyst-free Alkylation of Aromatic Amines with Aldehydes, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050012