Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions

Title:Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions

Volume: 20 Issue: 3

Author(s): Thomas W.Y. Lee, Nathan A. Boersen, H.W. Hui, S.F. Chow, K.Y. Wan and Albert H.L. Chow

Affiliation:

Keywords: Amorphous solid dispersion, polymer carrier, glass transition, molecular mobility, physical stability, amorphization technologies.

Abstract: Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.

Cite this article as:

Lee W.Y. Thomas, Boersen A. Nathan, Hui H.W., Chow S.F., Wan K.Y. and Chow H.L. Albert, Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions, Current Pharmaceutical Design 2014; 20 (3) . https://dx.doi.org/10.2174/13816128113199990396