Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones

Title:Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones

Volume: 10 Issue: 3

Author(s): Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen and Liang-Xian Liu

Affiliation:

Keywords: Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.

Abstract: A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.

Cite this article as:

Qin Wen-Bing, Chang Qiong, Luo Hai-Qinq, Bao Yun-Hong, Chen Zheng-Wang and Liu Liang-Xian, Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030012