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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Post-assembly Peptide Modifications by Chemical Methods

Author(s): Sambasivarao Kotha and Kakali Lahiri

Volume 12, Issue 7, 2005

Page: [849 - 875] Pages: 27

DOI: 10.2174/0929867053507333

Price: $65

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Abstract

The demand for peptide drugs is increasing and in this context, “post-assembly (or posttranslational) peptide modification strategies” by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.

Keywords: sequencing, human genome, peptide, oxidation, biomimetic cyclization, crosscoupling reactions, photoaffinity


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