Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Title: Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Volume: 8 Issue: 5

Author(s): Ravindra K. Rawal, V. R. Solomon, Yenamandra S. Prabhakar, S. B. Katti and E. De Clercq

Affiliation:

Keywords: thiazolidinones, metathiazanones, anti-hiv agents, nnrtis, dicyclohexylcarbodiimide (dcc)

Abstract: selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

Cite this article as:

Rawal K. Ravindra, Solomon R. V., Prabhakar S. Yenamandra, Katti B. S. and De Clercq E., Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents, Combinatorial Chemistry & High Throughput Screening 2005; 8 (5) . https://dx.doi.org/10.2174/1386207054546496

DOI https://dx.doi.org/10.2174/1386207054546496	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402