Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities

Title:Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities

Volume: 10 Issue: 6

Author(s): Murat Sukuroglu, Cem Yamali, Didem Tiryaki, Fatma Kaynak Onurdag, Esra Akkol and Deniz Songul Dogruer

Affiliation:

Keywords: 3(2H)-Pyridazinone, Acetohydrazide, Analgesic activity, Anti-inflammatory activity, Antibacterial activity, Antifungal activity.

Abstract: In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by ¹H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.

Cite this article as:

Sukuroglu Murat, Yamali Cem, Tiryaki Didem, Onurdag Fatma Kaynak, Akkol Esra and Dogruer Deniz Songul, Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060006